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As seen on The Joe Rogan Experience - Watch video

Built from
the cell up.

This page explores the biology behind NORTH Performance — every ingredient, every dose, and the evidence behind why it's there. It's written for people who want to understand what they're taking, not simply be told that it works.

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Performance is a system

Most supplements are built around a single desired outcome: more power, sharper focus, a bigger pump, faster recovery. But human performance is not a single pathway. It is shaped by an interconnected biological network in which power production, hydration, recovery, cognition, stress response, metabolism, immune function, and connective-tissue health influence one another. When one area is under-supported, the effects can extend beyond it—shaping how the body feels, performs, adapts, and recovers under real-world demands.

That is a fundamental limitation of much of modern supplementation. Short-term outputs can be valuable, but a narrow focus may overlook the physiological foundations that support consistency and long-term capacity. Performance is not built on one ingredient or one mechanism. It reflects multiple systems working together: generating power, managing stress, supporting recovery, maintaining tissue function, and adapting to physical and cognitive demands over time.

Black and white close-up photo of a cyclist riding a bicycle on a road, with a yellow quote overlaid at the bottom left: 'True performance is not built from a single ingredient or mechanism. It emerges from multiple systems operating efficiently together.

That systems-first philosophy is the foundation of NORTH Performance. Rather than formulating around trends, stimulants, or isolated mechanisms, we built Foundation around seven interrelated domains that together form the foundations of performance, recovery, resilience, and long-term health.

The goal was never to create another quick-fix supplement. The goal was to build a daily system that supports the biology underlying how humans perform, recover, adapt, and stay in the game for the long haul.


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Seven performance domains. One solution.

Watch video: Seven Performance Domains

NORTH Foundation is organized around seven interconnected performance domains. Each domain is supported by ingredients that have been studied in relevant contexts, with doses selected in reference to the published research.

These are not arbitrary marketing categories. They are a practical framework for the biological functions that shape how you generate power, recover, think, move, and adapt over time.

Photo of a mountain biker in action. There is an icon on top of the image. Cellular Power & Mitochondrial Health How cells produce power and adapt to changing power demands.
Cellular Power & Mitochondrial Health

The engine room behind performance, recovery and longevity.

Mitochondria are our cellular engines, converting macronutrients into ATP - the fuel that powers your entire system. As you age, your mitochondrial efficiency declines. That means slower recovery, lower output, and a body that simply doesn't bounce back like it used to.

NORTH Performance works by targeting the mitochondrial health of the entire system - not just patching the problem up with short-term power boosts. Powered by researched doses of Uthever NMN, PQQ, Spermidine, B-complex and more, NORTH supports cellular power production, repair processes and mitochondrial quality control. All cylinders, all the way.

Performance is not driven by a single system. It emerges from a complex network of cellular processes working together, producing power, adapting to stress, repairing damage, and maintaining metabolic balance. At the center of this network are mitochondria, the cellular engines responsible for converting macronutrients into ATP, the usable fuel that powers life. When mitochondrial efficiency declines, the effects rarely stay isolated to an individual system. NORTH Foundation was designed around the idea that performance is a system, and cellular power is one of the foundational systems everything else depends on.

NORTH Foundation approaches cellular performance as an interconnected system rather than a single pathway. NMN and niacinamide help support NAD+ metabolism, a central component of cellular power production and repair processes. PQQ supports mitochondrial biogenesis, while spermidine supports autophagy, the cellular renewal process responsible for clearing damaged cellular components and maintaining mitochondrial quality control. Together with B-vitamins that support power metabolism, the formulation is designed to support the broader infrastructure of cellular performance rather than chasing a short-term power effect in isolation.

NMN

Spermidine

Vitamin B6

Vitamin B12

Folate

Niacinamide

Yoshino, M., et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547), 1224–1229. Key human RCT at North Performance dose demonstrates NMN improved glucose disposal and insulin-stimulated AKT phosphorylation in skeletal muscle.

Xiong, X., et al. (2024). NAD+-boosting agent NMN potently improves mitochondria stress response in Alzheimer’s disease via ATF4-dependent mitochondrial UPR. Cell Death & Disease, 15.

Performance & Recovery

Built for performance when your body is under pressure

You don't get peak performance without peak recovery. For the body to bounce back to its best, several systems need to work together: muscle protein synthesis, cellular power metabolism, hydration, immune function, tissue remodeling, cognition, healthy sleep cycles, and more.

NORTH Foundation packs in all the aminos, vitamins and electrolytes you need to support power metabolism, neuromuscular function and cellular resilience. For heavier training, NORTH Ultra takes it further: creatine for ATP regeneration, EAAs for muscle protein synthesis, tart cherry for recovery support, and beta-alanine for blood flow. No slowing you down.

Recovery is the process through which the body restores function and adapts to stress. This involves the coordinated regulation of muscle protein synthesis, cellular power metabolism, hydration, immune function, and tissue remodeling. Because these systems are highly interconnected, limitations in one area can influence recovery capacity in others, potentially affecting readiness, adaptation, and subsequent performance.

Rather than relying on stimulants or acute performance sensations, NORTH Foundation supports the biological systems involved in daily recovery and adaptation through nutrients involved in power metabolism, hydration, neuromuscular function, and cellular resilience. Ultra layers targeted performance substrates on top during periods of higher output, including creatine for ATP regeneration, EAAs for muscle protein synthesis, tart cherry for recovery support, and citrulline and beta-alanine for blood flow and high-intensity performance support.

Betaine (TMG)

Magnesium Malate

Vitamin D3

Zinc Glycinate

Creatine Monohydrate

Amino L40®

CherryPURE®

L-Citrulline

Beta-Alanine

Taurine

Sodium + Potassium

Lanhers, C., et al. (2017). Creatine supplementation and upper limb strength performance: a systematic review and meta-analysis. Sports Medicine, 47(1), 163–173.

Cholewa, J.M., et al. (2014). Effects of betaine on body composition, performance, and homocysteine thiolactone. Journal of the International Society of Sports Nutrition, 11(1), 32

Gut, Microbiome & Immune Function

The microbiome balance that centres the entire body

A healthy gut does a lot of heavy lifting for people who train. It supports digestion and nutrient absorption, immune function, normal inflammatory processes, and overall resilience. Because the gut and microbiome communicate with immune, metabolic, and nervous systems, disruption can extend beyond digestive comfort - shaping how the body responds to training, recovery, stress, and everyday demands.

NORTH includes a targeted postbiotic complex designed to support gut barrier integrity and healthy gut-immune communication. It all helps to build a more balanced gut microbiota, which strengthens resilience everywhere else. Happy gut, healthy body.

The gut does far more than digest food. It plays a central role in nutrient absorption and contains gut-associated lymphoid tissue (GALT), a network of immune tissue that constantly senses and responds to the intestinal environment. This creates ongoing communication between the digestive and immune systems. When gut health is disrupted, the effects may extend beyond digestion—shaping nutrient handling, immune function, comfort, and how the body responds to everyday physical and cognitive demands. For active people, those foundations matter when managing the cumulative demands of training, recovery, travel, and stress.

NORTH Foundation includes a targeted postbiotic complex designed to support gut-barrier and immune function. Unlike probiotics, which contain live microorganisms, postbiotics are non-living microbial preparations that do not depend on live bacterial viability or colonization in the gut. This gives postbiotics greater formulation stability while offering a complementary approach to supporting the gut–immune interface.

Totipro® PE0401 P

Bifidobacterium BLD

Lactobacillus LPD

Lactobacillus LAD

Lactobacillus LSD

Round, J., & Mazmanian, S. (2009). The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews Immunology, 9, 313–323.

Brain, Mood & Stress Resilience

A mental clarity that cuts through the noise

Performance is never just physical. When we are overwhelmed, overstimulated, travelling a lot, sleeping less, or just generally stressed, our nervous system will bear the brunt. Over time, that can impact our focus, recovery, mood, motivation, and overall resilience.

If the brain isn’t recovering, neither can the body. NORTH’s daily stack includes adaptogens, antioxidants and nutrients - like rhodiola, niacinamide, Ergothioneine, and active B-vitamins. These target the neurochemical pathways that manage stress, supporting your mental stamina, focus, and resilience under pressure. A new standard for brain power.

Performance demands are not entirely physical. Cognitive load, emotional stress, travel, sleep disruption, and constant stimulation all place stress on the nervous system. Over time, chronic stress impacts focus, recovery, mood, motivation, and overall resilience. Supporting brain metabolism and stress adaptation helps maintain mental clarity, cognitive endurance, and calm focus during periods of sustained demand.

NORTH Foundation combines adaptogenic compounds, antioxidants, and neurological support nutrients to help support cognitive resilience and stress adaptation. SalidroPure® Rhodiola extract provides concentrated salidrosides that support the body’s stress-response systems and mental stamina during periods of physical or psychological load. Ergothioneine supports cellular antioxidant defense in neurologically active tissues, while B-vitamins support neurotransmitter production and nervous system function. The formulation is designed to support cognitive performance, calm focus, and stress resilience without stimulants.

SalidroPure® RE

L-Ergothioneine

Vitamin B6

Vitamin B12

Folate

Niacinamide

Creatine

Anghelescu, I.G., et al. (2018). Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice, 22(4), 242–252. Key systematic review citing multiple RCTs demonstrating Rhodiola significantly reduced burnout, perceived stress, and fatigue-related cognitive impairment vs placebo.

Lekomtseva, Y., et al. (2017). Rhodiola rosea in subjects with prolonged or chronic fatigue symptoms. Complementary Medicine Research, 24(1), 46–52. Significant improvements in fatigue, cognitive function, and mood at 4 and 8 weeks.

Antioxidant, Vascular & Metabolic Function

Your body’s protection system against accumulated stress and damage

Cellular metabolism is the unsung hero of human performance. It influences everything from oxygen delivery to blood flow - and is key for performance and recovery. But how hard we work and play will create oxidative stress, which impacts your cellular health over time.

NORTH’s daily stack combines a range of plant compounds, antioxidant nutrients, and B-vitamins that help maintain vascular and metabolic function. Our S7™ plant blend helps with nitric oxide production and blood flow - while salidrosides, ergothioneine, and Vitamin C support your defenses against oxidative stress.

Cellular metabolism and vascular function influence nearly every aspect of human performance — from oxygen delivery and blood flow to power production and recovery. Intense training, environmental stress, and daily metabolic demands also generate oxidative stress, which can impact cellular health over time. Supporting vascular health, antioxidant defenses, and metabolic function helps maintain efficient circulation, nutrient delivery, and overall physiological resilience.

NORTH Foundation combines polyphenol-rich plant compounds, antioxidant nutrients, and mitochondrial support ingredients to help maintain vascular and metabolic function. The S7™ plant blend supports nitric oxide production and blood flow, while salidrosides, ergothioneine, and Vitamin C help support antioxidant defenses against oxidative stress. NMN and B-vitamins further support healthy metabolic pathways involved in cellular power production and mitochondrial function.

S7™ Plant Blend

NMN

Vitamin C

L-Ergothioneine

SalidroPure® Rhodiola

Green Tea Extract

Tart Cherry

Turmeric

Nemzer, B.V., et al. (2021). A double-blind, placebo-controlled, randomized, longitudinal study on the effects of a plant-based dietary supplement on nitric oxide and mitochondrial metabolic activity. Journal of Food Research, 10(2), 21–31. S7 at 50mg/day — North’s exact dose — produced a 53.4% increase in circulating nitric oxide bioavailability vs placebo.

Joint & Connective Tissue Function

The structural systems that keep your body durable over time

Every lift, every sprint, every landing - it all slowly adds cumulative stress to your joints and connective tissue. Eventually, that stress starts to catch up with us - with tendons, ligaments, cartilage and bone all prone to feeling the wear and tear.

NORTH’s daily stack supports connective tissue and joint health through nutrients like Vitamin C, Vitamin D3, Vitamin K2, magnesium, and calcium. Together, these support collagen formation, structural integrity, bone metabolism and musculoskeletal function. Your joints and tissue get the support they need to feel more comfortable, more mobile and more resilient under physical load. Down with the stiffness.

Tendons, ligaments, cartilage, bone, and the extracellular matrix form the connective infrastructure that allows the body to move efficiently, transfer muscle force, and tolerate load over time. Supporting collagen formation, joint integrity, and connective tissue health helps maintain mobility, structural resilience, and long-term physical function.

NORTH Foundation supports connective tissue and joint health through nutrients involved in collagen formation, structural integrity, and bone physiology. Vitamin C supports collagen synthesis, while Vitamin D3, Vitamin K2, magnesium, and calcium support healthy bone metabolism and musculoskeletal function. Promentum® calcium fructoborate was selected for its well-studied role in supporting joint comfort, mobility, and connective tissue resilience under physical load.

Promentum® CF

Vitamin C

Vitamin D3

Vitamin K2 MK-7

Magnesium Malate

Calcium

Pietrzkowski, Z., et al. (2014). Short-term efficacy of calcium fructoborate on subjects with knee discomfort. Clinical Interventions in Aging, 9, 895–899. Significant reductions in WOMAC and McGill scores vs placebo, with improvements at Day 7 maintained/improved at Day 14.

Pietrzkowski, Z., et al. (2018). Evaluation of once-daily versus twice daily dosing of calcium fructoborate on knee discomfort. Journal of Aging Research & Clinical Practice. Benefits maintained over 90-day duration.

Hydration & Electrolytes

The foundation behind endurance, output and performance under pressure

In high-demand environments, your body will burn through fluids, minerals and electrolytes faster than you realise. Even mild dehydration can impact your muscle contraction, nerve signaling, endurance, cognitive performance, and overall cellular function. For peak performance (both physically and mentally), hydration is key.

NORTH’s daily stack has a balanced electrolyte profile, where sodium, potassium, magnesium, and calcium all play essential roles in your cellular hydration, electrolyte balance and neuromuscular function. Even across back-to-back days of physical and mental demand, NORTH is designed to keep you balanced - and without the heavy sugar load found in conventional formulas. All the essentials. None of the nasties.

Fluid balance and electrolyte status affect muscle contraction, nerve signaling, endurance, cognitive performance, and overall cellular function. Even mild dehydration can impair physical and mental performance, particularly during training, travel, heat exposure, or demanding schedules.

NORTH Foundation includes a balanced electrolyte profile designed to support fluid balance, neuromuscular function, and cellular hydration. Sodium, potassium, magnesium, and calcium all play essential roles in muscle contraction, nerve transmission, and fluid regulation. Magnesium malate also contributes to aerobic power metabolism through its role in the Krebs cycle. The formulation was designed to support hydration as part of the broader physiological infrastructure that helps the body perform consistently under daily demand.

Sodium

Potassium

Chloride

Magnesium Malate

Calcium

ACSM Hydration Guidelines · ISSN Position Stands on Hydration and Electrolytes · Zhang et al., Nutrients (2017).

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How it works at the cellular level

Cellular Performance: For us, “cellular performance” isn’t a non-descript marketing term. It refers to the capacity of cells across all bodily systems and tissues to efficiently produce power, maintain metabolic homeostasis, respond to physiological stressors, regulate intracellular signaling pathways, and support repair and turnover processes necessary for tissue maintenance. These processes are primarily governed by mitochondrial bioenergetics, redox balance, nutrient sensing, inflammatory signaling, and protein quality-control systems.

The NORTH formulation strategy is based on the biological premise that physical and cognitive performance are constrained by cellular function. Accordingly, the formulation includes key ingredients with evidence supporting mitochondrial power metabolism, NAD+ biosynthesis, oxidative stress resilience, cellular signaling, hydration, and tissue remodeling pathways involved in maintaining high cellular function under conditions of stress, training, and aging.

Nutrients that support foundational biological systems

Power production, recovery, cognitive function, stress resilience, and tissue repair all depend on how efficiently cells can generate power, communicate, protect themselves, and adapt to stress. Rather than relying on stimulants or symptom-masking solutions, NORTH is formulated to provide doses of nutrients that support foundational biological systems that help maintain performance, resilience, and recovery over time.

Mechanism 1

Mitochondrial power production

Mitochondria are responsible for generating ATP — the power currency that powers the biochemical interactions of cells. NORTH Foundation and Ultra include ingredients such as creatine, NMN, PQQ, magnesium, niacinamide, and B-vitamins that support power metabolism, NAD+ production, and cellular power pathways involved in sustained physical and mental performance.

Summary: NORTH supports the cellular systems responsible for producing and sustaining power — not just masking fatigue.

Mechanism 2

Cellular signaling & stress response

Cells must constantly respond and adapt to a variety of mechanical, thermal, oxidative, inflammatory, and other environmental stressors. Whether cells succumb to or adapt to stress largely depends on their capacity to maintain power availability, preserve redox balance, regulate stress-response signaling pathways, and repair or remove damaged cellular components. Ingredients such as Rhodiola, tart cherry polyphenols, taurine, ergothioneine, and the S7 blend help support antioxidant defenses, nitric oxide signaling, and balanced stress-response pathways involved in recovery and resilience.

Summary: NORTH is designed to support how cells respond and adapt to stress — supporting key cellular processes that maintain cellular stress resilience.

Mechanism 3

Cellular repair & turnover

Tissue repair and successful adaptation depend on the cell’s ability to survive the stress and actively contribute to tissue remodeling during the recovery period. North Ultra includes EAAs, leucine, creatine, and betaine to support muscle protein synthesis, ATP regeneration, and cellular hydration, while ingredients such as spermidine and vitamin C support cellular maintenance and connective tissue integrity.

Summary: NORTH supports the biological processes involved in repair, recovery, and long-term tissue resilience.

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Foundation + Ultra: A layered system supporting peak performance

NORTH Foundation and NORTH Ultra were designed to function as complementary layers within the same physiological framework. Foundation provides daily support across all seven domains of cellular health and performance. Ultra adds targeted support for periods of higher physical demand, training intensity, and recovery load.

Rather than functioning as competing products, Foundation establishes the baseline nutritional and cellular support layer, while Ultra provides additional performance-oriented substrates involved in ATP regeneration, muscle protein synthesis, hydration, buffering capacity, and exercise recovery.

NORTH Foundation product tube

Foundation

Foundation + Ultra

Form factor
Daily effervescent tablets
Foundation + Ultra performance sachet
Domains covered
All 7 domains
All 7 domains + targeted support for high-output performance pathways
Best for
Daily nutrition, wellness, and foundational cellular support
Higher training loads, performance demands, and recovery support
Daily routine
Daily foundational use
Foundation daily + Ultra around training or high-output periods
Key additions in Ultra
—
Creatine, l-citrulline, beta-alanine, EAAs, taurine, tart cherry

Ultra is designed to be used alongside Foundation — not in place of it — creating a layered approach to daily health, performance, and recovery support.

NORTH Ultra product sachet

Dose, form & consistency

An ingredient is only as effective as the dose it’s delivered at. This sounds obvious, but it’s one of the most important — and most frequently overlooked — distinctions in supplement formulation. The presence of an ingredient on a label and the delivery of that ingredient at a clinically meaningful dose are two very different things.

The difference between a supplement that works and one that doesn’t is rarely the ingredient itself. NMN at 50mg is not the same as NMN at 250mg. Rhodiola at a generic 3% salidroside extract is not the same as SalidroPure™ at 98.5%. Citrulline at 2g is not the same as L-Citrulline Base at 6g. Form matters. Dose matters. And the only way to know whether a dose is meaningful is to look at the published human evidence behind it.

Active ingredients in Foundation and Ultra are dosed at or near the level used in published human clinical trials. NMN at 250mg — matching the RCT published in Science. S7 at 50mg — the higher-dose arm that produced the strongest nitric oxide effect. Promentum at 216mg — matching the dose used across four published joint health trials. L-Citrulline at 6g — the dose that produced a 53% increase in training performance in a double-blind trial. Every formula decision was made around the evidence first.

But dose alone isn’t enough. The third variable — one that rarely gets discussed — is consistency. Many of Foundation’s key ingredients, including NMN, spermidine, and the B-complex, produce benefits that accumulate over weeks of daily use rather than acutely after a single dose. Beta-Alanine in Ultra loads carnosine stores progressively over 4–6 weeks. Creatine saturates phosphocreatine stores with consistent daily intake. The science on supplement adherence is clear: even well-dosed products produce diminished outcomes when taken inconsistently. This is why Foundation was designed as an effervescent tablet — a format with consistently higher adherence rates than capsules or powders in clinical compliance studies — and why both products are formulated to be genuinely easy to take every day, not just on the days you remember.

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A vote from Dr. Reynolds

As a surgeon, I spend my life around recovery, performance, injury, aging, and human resilience. I work with elite athletes, high performers, and everyday people who simply want to feel strong, capable, and healthy for as long as possible. Over the years, I became increasingly frustrated by the gap between what the science supports and what most supplements actually deliver.

Too many products are built around short-term stimulation, isolated mechanisms, or a single headline ingredient. I wanted to create something different: a system grounded in cellular foundations, ingredients selected in reference to published human research, and the interconnected biological functions that shape performance, recovery, power, and resilience.

NORTH was designed for people who push themselves — in sport, business, training, parenting, and life. The goal was never to create another performance supplement. The goal was to build a daily system that helps people stay in the game longer, recover better, and keep doing the things they love at a high level for decades to come.

Dr Masi Reynolds,

Board-Certified Orthopedic Surgeon · Sports & Regenerative Medicine

Co-Founder & Chief Medical Officer, NORTH Performance

Trusted by pro athletes and elite performers worldwide

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Every ingredient. Every dose. Every reason.

Nothing hidden, nothing vague

We don’t use proprietary blends. Every active ingredient in Foundation and Ultra is fully disclosed, including its amount per serving and why it is included. No fairy dusting. No hidden quantities. Every ingredient and dose is selected in reference to the published research.

Download comprehensive ingredients document (PDF) ›

Peer-reviewed, not just promised

The claims and ingredient descriptions on this page are supported by a comprehensive body of peer-reviewed human clinical evidence. For the complete clinical reference library — organized by domain and ingredient — download the full NORTH Performance Scientific Claims Repository.

Download scientific claims repository (PDF) ›

NORTH Performance product family including Foundation and Ultra, as well as the NORTH drink bottle.

Ready to build your foundation?

You’ve seen the science. You know the doses. You understand why every ingredient is there.

NORTH Performance was built for people who take their biology seriously — athletes, high performers, and anyone who wants to keep doing what they love at a high level for as long as possible. Foundation supports the daily biological infrastructure behind power, resilience, recovery, and long-term health. Ultra adds targeted support for training, output, and recovery during periods of higher demand. Together, they create a layered approach to human performance built around transparency, clinical dosing, and evidence-led formulation.

If you have questions about the science, ingredients, or how to use the system, reach out to us.

Pre-order Foundation + Ultra
Pre-order now · Priority shipping in September
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Trusted by pro athletes and elite performers worldwide